Anti-APTX / Aprataxin Antibody
Catalog No : IGX-43243
262.00€
188.00€
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| Description | DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PMID:15380105, PMID:15044383, PMID:16964241, PMID:17276982, PMID:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PMID:16964241, PMID:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PMID:16964241, PMID:17276982, PMID:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PMID:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) . | ||
|---|---|---|---|
| Other names | Aprataxin, EC 3.1.11.7, EC 3.1.12.2, Forkhead-associated domain histidine triad-like protein, FHA-HIT, APTX, AXA1 | ||
| Cellular localization | Nucleoplasm, Nucleolus, Cytoplasm | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q7Z2E3 | ||
| Product name | Anti-APTX / Aprataxin Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43243 | ||
| Supplier’s Catalog No | IGX-43243 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Aprataxin protein (92-161AA) | ||
| Specificity | APTX antibody detects endogenous level of APTX protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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