Anti-SBF2 Antibody
Catalog No : IGX-44207
262.00€
188.00€
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| Description | Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PMID:20937701, PMID:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PMID:20937701, PMID:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PMID:25648148). Acts as an adapter for the phosphatase MTMR2 . Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate . | ||
|---|---|---|---|
| Other names | Myotubularin-related protein 13, SET-binding factor 2, SBF2, CMT4B2 KIAA1766 MTMR13 | ||
| Cellular localization | Endosome Membrane, Peripheral Membrane, Cytoplasm, Perinuclear Region, Membrane, Axon | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q86WG5 | ||
| Product name | Anti-SBF2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44207 | ||
| Supplier’s Catalog No | IGX-44207 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Myotubularin-related protein 13 protein (1585-1813AA) | ||
| Specificity | SBF2 antibody detects endogenous level of SBF2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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