Anti-MEGF10 Antibody
Catalog No : IGX-44218
262.00€
188.00€
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| Description | Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PMID:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PMID:20828568, PMID:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PMID:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PMID:28498977, Ref. 14). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PMID:17498693, PMID:17643423, PMID:20828568, PMID:22101682, PMID:27170117, PMID:28498977). | ||
|---|---|---|---|
| Other names | Multiple epidermal growth factor-like domains protein 10, Multiple EGF-like domains protein 10, MEGF10, KIAA1780 | ||
| Cellular localization | Membrane, Single-Pass Type I Membrane, Phagocytic Cup | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q96KG7 | ||
| Product name | Anti-MEGF10 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44218 | ||
| Supplier’s Catalog No | IGX-44218 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Multiple epidermal growth factor-like domains protein 10 protein (123-314AA) | ||
| Specificity | MEGF10 antibody detects endogenous level of MEGF10 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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