Anti-WAC Antibody
Catalog No : IGX-44233
262.00€
188.00€
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| Description | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PMID:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PMID:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PMID:21329877). Positive regulator of amino acid starvation-induced autophagy (PMID:22354037). Also acts as a negative regulator of basal autophagy (PMID:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PMID:26812014). May negatively regulate the ubiquitin proteasome pathway (PMID:21329877). | ||
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| Other names | WW domain-containing adapter protein with coiled-coil, WAC, KIAA1844 | ||
| Cellular localization | Nucleus Speckle, Nucleus | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9BTA9 | ||
| Product name | Anti-WAC Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44233 | ||
| Supplier’s Catalog No | IGX-44233 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human WW domain-containing adapter protein with coiled-coil protein (10-102AA) | ||
| Specificity | WAC antibody detects endogenous level of WAC protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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