Anti-EHD3 Antibody
Catalog No : IGX-44244
262.00€
188.00€
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| Description | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PMID:25686250). In vitro causes tubulation of endocytic membranes (PMID:24019528). Binding to phosphatidic acid induces its membrane tubulation activity . Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PMID:16251358, PMID:17233914, PMID:19139087, PMID:23781025). Involved in the recycling of internalized D1 dopamine receptor (PMID:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PMID:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction . In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function . Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PMID:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing . Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PMID:25686250). | ||
|---|---|---|---|
| Other names | EH domain-containing protein 3, PAST homolog 3, EHD3, EHD2 PAST3 | ||
| Cellular localization | Membrane, Peripheral Membrane, , Cilium Membrane, Recycling Endosome Membrane | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9NZN3 | ||
| Product name | Anti-EHD3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44244 | ||
| Supplier’s Catalog No | IGX-44244 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human EH domain-containing protein 3 protein (269-498AA) | ||
| Specificity | EHD3 antibody detects endogenous level of EHD3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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