Anti-SMYD2 Antibody
Catalog No : IGX-44251
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. | ||
|---|---|---|---|
| Other names | N-lysine methyltransferase SMYD2, EC 2.1.1.-, HSKM-B, Histone methyltransferase SMYD2, EC 2.1.1.43, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2, SMYD2, KMT3C | ||
| Cellular localization | Cytosol, Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9NRG4 | ||
| Product name | Anti-SMYD2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44251 | ||
| Supplier’s Catalog No | IGX-44251 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human N-lysine methyltransferase SMYD2 protein (115-272AA) | ||
| Specificity | SMYD2 antibody detects endogenous level of SMYD2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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