Anti-CLDN1 / Claudin 1 Antibody
Catalog No : IGX-44260
262.00€
188.00€
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| Description | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PMID:23407391). (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes (PMID:17325668, PMID:20375010). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PMID:20375010). Acts as a receptor for dengue virus (PMID:24074594). | ||
|---|---|---|---|
| Other names | Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1 SEMP1 | ||
| Cellular localization | Plasma Membrane, Membrane, Multi-Pass Membrane, Basolateral Membrane, Tight Junction | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O95832 | ||
| Product name | Anti-CLDN1 / Claudin 1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44260 | ||
| Supplier’s Catalog No | IGX-44260 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Claudin-1 protein (24-161AA) | ||
| Specificity | CLDN1 antibody detects endogenous level of CLDN1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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