Anti-BAAT Antibody
Catalog No : IGX-44316
262.00€
188.00€
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| Description | Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PMID:12810727, PMID:8034703, PMID:2037576, PMID:12239217). More than 95% of the BAs are N-acyl amidates with glycine and taurine (PMID:8034703). Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (PMID:12810727). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (PMID:12810727). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (PMID:12810727, PMID:8034703, PMID:12239217). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (PMID:12810727). | ||
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| Other names | Bile acid-CoA:amino acid N-acyltransferase, BACAT, BAT, EC 2.3.1.65, Glycine N-choloyltransferase, Long-chain fatty-acyl-CoA hydrolase, EC 3.1.2.2, BAAT | ||
| Cellular localization | Peroxisome, Cytosol | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q14032 | ||
| Product name | Anti-BAAT Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44316 | ||
| Supplier’s Catalog No | IGX-44316 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Bile acid-CoA:amino acid N-acyltransferase protein (313-400AA) | ||
| Specificity | BAAT antibody detects endogenous level of BAAT protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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