Anti-WNT7A Antibody
Catalog No : IGX-44360
262.00€
188.00€
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| Description | Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway . Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PMID:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PMID:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes . Required for normal neural stem cell proliferation in the hippocampus dentate gyrus . Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation . Promotes formation of synapses via its interaction with FZD5 . | ||
|---|---|---|---|
| Other names | Protein Wnt-7a, WNT7A | ||
| Cellular localization | Extracellular Matrix, Secreted | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O00755 | ||
| Product name | Anti-WNT7A Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44360 | ||
| Supplier’s Catalog No | IGX-44360 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Protein Wnt-7a protein (126-302AA) | ||
| Specificity | WNT7A antibody detects endogenous level of WNT7A protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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