Anti-KIF14 Antibody
Catalog No : IGX-44364
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity . Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PMID:24784001, PMID:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PMID:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PMID:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PMID:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division . Also is required for chromosome congression and alignment during mitotic cell cycle process (PMID:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PMID:23209302). | ||
|---|---|---|---|
| Other names | Kinesin-like protein KIF14, KIF14, KIAA0042 | ||
| Cellular localization | Nucleus, Cytoskeleton, Spindle, Cytoplasm, Midbody | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q15058 | ||
| Product name | Anti-KIF14 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44364 | ||
| Supplier’s Catalog No | IGX-44364 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Kinesin-like protein KIF14 protein (261-531AA) | ||
| Specificity | KIF14 antibody detects endogenous level of KIF14 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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