Anti-HPGD Antibody
Catalog No : IGX-44387
262.00€
188.00€
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| Description | Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels (PMID:15574495, PMID:16828555, PMID:8086429). Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (PMID:10837478). Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE) (PMID:21916491). Has hydroxylated docosahexaenoic acid metabolites as substrates (PMID:25586183). Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions (PMID:16757471, PMID:22844113). | ||
|---|---|---|---|
| Other names | 15-hydroxyprostaglandin dehydrogenase [NAD,+,], 15-PGDH, EC 1.1.1.141, Prostaglandin dehydrogenase 1, Short chain dehydrogenase/reductase family 36C member 1, HPGD, PGDH1 SDR36C1 | ||
| Cellular localization | Cytoplasm | ||
| Research area | Immunology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P15428 | ||
| Product name | Anti-HPGD Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44387 | ||
| Supplier’s Catalog No | IGX-44387 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human 15-hydroxyprostaglandin dehydrogenase [NAD(+)] protein (14-130AA) | ||
| Specificity | HPGD antibody detects endogenous level of HPGD protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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