Anti-BACE1 Antibody
Catalog No : IGX-44408
262.00€
188.00€
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| Description | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PMID:10656250, PMID:10677483, PMID:20354142). Cleaves CHL1 . | ||
|---|---|---|---|
| Other names | Beta-secretase 1, EC 3.4.23.46, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE KIAA1149 | ||
| Cellular localization | Golgi Apparatus, Trans-Golgi Network, Membrane, Single-Pass Type I Membrane, Lysosome, Endoplasmic Reticulum, Endosome, Late Endosome, Early Endosome, Recycling Endosome, Cell Surface, Cytoplasmic Vesicle Membrane, Membrane, Membrane Raft, Axon, Dendrite | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P56817 | ||
| Product name | Anti-BACE1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44408 | ||
| Supplier’s Catalog No | IGX-44408 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Beta-secretase 1 protein (46-155AA) | ||
| Specificity | BACE1 antibody detects endogenous level of BACE1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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