Anti-HMGB2 Antibody
Catalog No : IGX-44474
262.00€
188.00€
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| Description | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PMID:7797075, PMID:11909973, PMID:19522541, PMID:18413230, PMID:19965638, PMID:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) . Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors . In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PMID:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PMID:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity . Involved in modulation of neurogenesis probably by regulation of neural stem proliferation . Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway . | ||
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| Other names | High mobility group protein B2, High mobility group protein 2, HMG-2, HMGB2, HMG2 | ||
| Cellular localization | Chromosome, Cytoplasm, Nucleus, Secreted | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P26583 | ||
| Product name | Anti-HMGB2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44474 | ||
| Supplier’s Catalog No | IGX-44474 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human High mobility group protein B2 protein (43-185AA) | ||
| Specificity | HMGB2 antibody detects endogenous level of HMGB2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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