Anti-MRE11A Antibody
Catalog No : IGX-44511
262.00€
188.00€
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| Description | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PMID:9651580, PMID:9590181, PMID:9705271, PMID:11741547, PMID:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PMID:9651580, PMID:9590181, PMID:9705271, PMID:11741547, PMID:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PMID:9651580, PMID:9590181, PMID:9705271, PMID:11741547, PMID:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PMID:9651580, PMID:9590181, PMID:9705271, PMID:11741547, PMID:29670289, PMID:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PMID:15064416). In telomeres the MRN complex may modulate t-loop formation (PMID:10888888). | ||
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| Other names | Double-strand break repair protein MRE11, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A, MRE11, HNGS1 MRE11A | ||
| Cellular localization | Nucleus, Telomere, Chromosome | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P49959 | ||
| Product name | Anti-MRE11A Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44511 | ||
| Supplier’s Catalog No | IGX-44511 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Double-strand break repair protein MRE11A protein (1-205AA) | ||
| Specificity | MRE11A antibody detects endogenous level of MRE11A protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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