Anti-DDX4 Antibody
Catalog No : IGX-44558
262.00€
188.00€
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| Description | ATP-dependent RNA helicase required during spermatogenesis (PMID:10920202, PMID:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity . Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons . Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle . Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs . | ||
|---|---|---|---|
| Other names | Probable ATP-dependent RNA helicase DDX4, EC 3.6.4.13, DEAD box protein 4, Vasa homolog, DDX4, VASA | ||
| Cellular localization | Cytoplasm, Perinuclear Region | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9NQI0 | ||
| Product name | Anti-DDX4 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44558 | ||
| Supplier’s Catalog No | IGX-44558 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Probable ATP-dependent RNA helicase DDX4 protein (1-223AA) | ||
| Specificity | DDX4 antibody detects endogenous level of DDX4 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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