Anti-KCNK1 Antibody
Catalog No : IGX-44585
262.00€
188.00€
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| Description | Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PMID:15820677, PMID:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K+ ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na+ at subphysiological K+ levels and upon acidification of the extracellular medium (PMID:21653227, PMID:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PMID:8605869, PMID:8978667, PMID:15820677, PMID:21653227, PMID:22431633, PMID:23169818, PMID:25001086). Channel activity is modulated by activation of serotonin receptors . Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes . Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PMID:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PMID:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential . Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability . In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 . Required for normal ion and water transport in the kidney . Contributes to the regulation of the resting membrane potential of pancreatic beta cells . The low channel activity of homodimeric KCNK1 may be due to sumoylation (PMID:15820677, PMID:20498050, PMID:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PMID:19959478). | ||
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| Other names | Potassium channel subfamily K member 1, Inward rectifying potassium channel protein TWIK-1, Potassium channel K2P1, Potassium channel KCNO1, KCNK1, HOHO1 KCNO1 TWIK1 | ||
| Cellular localization | Membrane, Multi-Pass Membrane, Synaptic Membrane, Apical Membrane, Recycling Endosome, Cytoplasmic Vesicle, Perikaryon, Dendrite, Cell Projection | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O00180 | ||
| Product name | Anti-KCNK1 Antibody | ||
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| Catalog No | IGX-44585 | ||
| Supplier’s Catalog No | IGX-44585 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Potassium channel subfamily K member 1 protein (268-336AA) | ||
| Specificity | KCNK1 antibody detects endogenous level of KCNK1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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