Anti-GGT1 Antibody
Catalog No : IGX-44590
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive. | ||
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| Other names | Glutathione hydrolase 1 proenzyme, EC 3.4.19.13, Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, GGT 1, EC 2.3.2.2, Leukotriene-C4 hydrolase, EC 3.4.19.14, CD antigen CD224, [Cleaved into: Glutathione hydrolase 1 heavy chain, Glutathione hydrolase 1 light chain], GGT1, GGT | ||
| Cellular localization | Membrane, Single-Pass Type Ii Membrane | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P19440 | ||
| Product name | Anti-GGT1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44590 | ||
| Supplier’s Catalog No | IGX-44590 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Gamma-glutamyltranspeptidase 1 protein (13-225AA) | ||
| Specificity | GGT1 antibody detects endogenous level of GGT1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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