Anti-SLC39A8 Antibody
Catalog No : IGX-44605
262.00€
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| Description | Electroneutral transporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis or immunity (PMID:12504855, PMID:22898811, PMID:23403290, PMID:29337306, PMID:26637978, PMID:29453449). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation, a bicarbonate and a selenite anion or yet a metal cation and two bicarbonate anions (PMID:27166256, PMID:31699897). May also transport iron, mercury and cobalt through membranes (PMID:22898811). Beside these endogenous cellular substrates, also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PMID:27466201). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PMID:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PMID:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PMID:23403290, PMID:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PMID:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries . At the apical membrane of hepatocytes, reclaims manganese from the bile and regulates, through the systemic levels of the nutrient, the activity of manganese-dependent enzymes (PMID:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PMID:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PMID:26637978, PMID:31699897). Through manganese cellular uptake also participates in mitochondrial proper function (PMID:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PMID:19401385). | ||
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| Other names | Zinc transporter ZIP8, BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, LZT-Hs6, Solute carrier family 39 member 8, Zrt- and Irt-like protein 8, ZIP-8, SLC39A8, BIGM103 ZIP8 | ||
| Cellular localization | Membrane, Multi-Pass Membrane, Apical Membrane, Basolateral Membrane, Lysosome Membrane | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9C0K1 | ||
| Product name | Anti-SLC39A8 Antibody | ||
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| Catalog No | IGX-44605 | ||
| Supplier’s Catalog No | IGX-44605 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Zinc transporter ZIP8 protein (30-132AA) | ||
| Specificity | SLC39A8 antibody detects endogenous level of SLC39A8 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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