Anti-NOTCH2 Antibody
Catalog No : IGX-44621
262.00€
188.00€
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| Description | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PMID:21378985, PMID:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs . Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PMID:29149593). Positively regulates self-renewal of liver cancer cells (PMID:25985737). | ||
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| Other names | Neurogenic locus notch homolog protein 2, Notch 2, hN2, [Cleaved into: Notch 2 extracellular truncation, N2ECD, Notch 2 intracellular domain, N2ICD,], NOTCH2 | ||
| Cellular localization | Plasma Membrane, Membrane, Single-Pass Type I Membrane, Nucleus, Cytoplasm | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q04721 | ||
| Product name | Anti-NOTCH2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44621 | ||
| Supplier’s Catalog No | IGX-44621 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Neurogenic locus notch homolog protein 2 protein (59-250AA) | ||
| Specificity | NOTCH2 antibody detects endogenous level of NOTCH2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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