Anti-CDH1 / E-Cadherin Antibody (CD324)
Catalog No : IGX-44648
262.00€
188.00€
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| Description | Cadherins are calcium-dependent cell adhesion proteins (PMID:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PMID:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. | ||
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| Other names | Cadherin1, Cadherin 1, Cadherin-1, CAM 120/80, Epithelial cadherin, E cadherin, Uvomorulin, CD antigen CD324, [Cleaved into: E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3], CDHE UVO | ||
| Cellular localization | Golgi Apparatus, Trans-Golgi Network, Membrane, Single-Pass Type I Membrane, Endosome, Adherens Junction | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P12830 | ||
| Product name | Anti-CDH1 / E-Cadherin Antibody (CD324) | ||
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| Catalog No | IGX-44648 | ||
| Supplier’s Catalog No | IGX-44648 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cadherin-1 protein (153-641AA) | ||
| Specificity | CDH1 antibody detects endogenous level of CDH1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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