Anti-CYP2B6 Antibody
Catalog No : IGX-44668
262.00€
188.00€
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| Description | A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PMID:21289075, PMID:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PMID:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PMID:21289075, PMID:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PMID:11695850, PMID:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PMID:11695850). Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs. | ||
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| Other names | Cytochrome P450 2B6, EC 1.14.13.-, 1,4-cineole 2-exo-monooxygenase, CYPIIB6, Cytochrome P450 IIB1, CYP2B6 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Peripheral Membrane, Microsome Membrane | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P20813 | ||
| Product name | Anti-CYP2B6 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44668 | ||
| Supplier’s Catalog No | IGX-44668 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytochrome P450 2B6 protein (250-343AA) | ||
| Specificity | CYP2B6 antibody detects endogenous level of CYP2B6 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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