Anti-RAB3A Antibody
Catalog No : IGX-44679
262.00€
188.00€
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| Description | Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane . Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane . Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed . Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells . Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PMID:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PMID:22248876, PMID:30599141). Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT . | ||
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| Other names | Ras-related protein Rab-3A, RAB3A | ||
| Cellular localization | Membrane, Lipid-Anchor, , Lysosome, Cytosol, Secretory Vesicle | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P20336 | ||
| Product name | Anti-RAB3A Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44679 | ||
| Supplier’s Catalog No | IGX-44679 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Ras-related protein Rab-3A protein (1-220AA) | ||
| Specificity | RAB3A antibody detects endogenous level of RAB3A protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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