Anti-UBE2D2 Antibody
Catalog No : IGX-44682
262.00€
188.00€
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| Description | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. | ||
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| Other names | Ubiquitin-conjugating enzyme E2 D2, EC 2.3.2.23,, E3-independent, E2 ubiquitin-conjugating enzyme D2, EC 2.3.2.24, E2 ubiquitin-conjugating enzyme D2, Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2,17,KB 2, Ubiquitin-conjugating enzyme E2-17 kDa 2, Ubiquitin-protein ligase D2, p53-regulated ubiquitin-conjugating enzyme 1, UBE2D2, PUBC1 UBC4 UBC5B UBCH4 UBCH5B | ||
| Cellular localization | Cytosol, Extracellular Exosome, Nucleus, Nucleoplasm, -Containing Complex, Ubiquitin Ligase Complex | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P62837 | ||
| Product name | Anti-UBE2D2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44682 | ||
| Supplier’s Catalog No | IGX-44682 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Ubiquitin-conjugating enzyme E2 D2 protein (1-147AA) | ||
| Specificity | UBE2D2 antibody detects endogenous level of UBE2D2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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