Anti-ITPR1 Antibody
Catalog No : IGX-44685
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PMID:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways | ||
|---|---|---|---|
| Other names | Inositol 1,4,5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP3R 1, InsP3R1, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptor, ITPR1, INSP3R1 | ||
| Cellular localization | Endoplasmic Reticulum | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q14643 | ||
| Product name | Anti-ITPR1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44685 | ||
| Supplier’s Catalog No | IGX-44685 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Inositol 1,4,5-trisphosphate receptor type 1 protein (1707-1966AA) | ||
| Specificity | ITPR1 antibody detects endogenous level of ITPR1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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