| Description |
Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking (PMID:20949042, PMID:22012985, PMID:26824392, PMID:29125462, PMID:28720718, PMID:29127255, PMID:30398148, PMID:29212815, PMID:30635421, PMID:21850687, PMID:23395371, PMID:17114044, PMID:24687852, PMID:26014385, PMID:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PMID:26824392, PMID:28720718, PMID:29127255, PMID:30398148, PMID:29212815, PMID:29125462, PMID:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PMID:26824392, PMID:28720718, PMID:29127255, PMID:30398148, PMID:29212815, PMID:29125462, PMID:30635421, PMID:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PMID:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PMID:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PMID:29125462, PMID:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PMID:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PMID:17114044). Plays a role in synaptic vesicle trafficking (PMID:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PMID:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PMID:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PMID:22012985). Phosphorylates PRDX3 (PMID:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PMID:28720718). Independent of its kinase activity, inhibits the proteosomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PMID:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PMID:18230735, PMID:26824392, PMID:29125462, PMID:28720718, PMID:29212815). |
| Cellular localization
|
Golgi Apparatus Membrane, Peripheral Membrane, Mitochondrion Outer Membrane, Lysosome, Endoplasmic Reticulum Membrane, Endosome, Cytoplasmic Vesicle, Perikaryon, Axon, Dendrite, Synaptic Vesicle Membrane |
