Anti-WDFY3 Antibody
Catalog No : IGX-44733
262.00€
188.00€
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| Description | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PMID:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PMID:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 . Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PMID:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway . After cytokinetic abscission, involved in midbody remnant degradation (PMID:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PMID:15292400). | ||
|---|---|---|---|
| Other names | WD repeat and FYVE domain-containing protein 3, Autophagy-linked FYVE protein, Alfy, WDFY3, KIAA0993 | ||
| Cellular localization | Nucleus, Nucleus Membrane, Pml Body, Cytosol, Membrane, Peripheral Membrane, , Perikaryon, Axon | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q8IZQ1 | ||
| Product name | Anti-WDFY3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44733 | ||
| Supplier’s Catalog No | IGX-44733 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA) | ||
| Specificity | WDFY3 antibody detects endogenous level of WDFY3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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