Anti-PDE8A Antibody
Catalog No : IGX-44747
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PMID:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PMID:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PMID:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PMID:23509299). | ||
|---|---|---|---|
| Other names | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, EC 3.1.4.53, PDE8A | ||
| Cellular localization | Cytosol, Extracellular Exosome | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O60658 | ||
| Product name | Anti-PDE8A Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44747 | ||
| Supplier’s Catalog No | IGX-44747 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A protein (596-829AA) | ||
| Specificity | PDE8A antibody detects endogenous level of PDE8A protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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