Anti-FASLG Antibody
Catalog No : IGX-44779
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PMID:26334989, PMID:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PMID:9228058, PMID:7528780, PMID:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses . TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance . Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PMID:27806260). Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways . Can induce apoptosis but does not appear to be essential for this process (PMID:27806260). FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. | ||
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| Other names | Tumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD antigen CD178, [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form, Tumor necrosis factor ligand superfamily member 6, soluble form, Receptor-binding FasL ectodomain, Soluble Fas ligand, sFasL, ADAM10-processed FasL form, APL, FasL intracellular domain, FasL ICD, SPPL2A-processed FasL form, SPA,], FASLG, APT1LG1 CD95L FASL TNFSF6 | ||
| Cellular localization | Membrane, Single-Pass Type Ii Membrane, Lysosome Lumen, Cytoplasmic Vesicle Lumen, Secreted, Nucleus | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P48023 | ||
| Product name | Anti-FASLG Antibody | ||
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| Catalog No | IGX-44779 | ||
| Supplier’s Catalog No | IGX-44779 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Tumor necrosis factor ligand superfamily member 6 protein (103-281AA) | ||
| Specificity | FASLG antibody detects endogenous level of FASLG protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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