Anti-CD14 Antibody
Catalog No : IGX-44791
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Coreceptor for bacterial lipopolysaccharide (PMID:1698311, PMID:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PMID:20133493, PMID:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PMID:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PMID:16880211). Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- (PMID:23880187). | ||
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| Other names | Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD antigen CD14, [Cleaved into: Monocyte differentiation antigen CD14, urinary form, Monocyte differentiation antigen CD14, membrane-bound form], CD14 | ||
| Cellular localization | Golgi Apparatus, Membrane, Gpi-Anchor, Secreted, Membrane Raft | ||
| Research area | Immunology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P08571 | ||
| Product name | Anti-CD14 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44791 | ||
| Supplier’s Catalog No | IGX-44791 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Monocyte differentiation antigen CD14 protein (20-345AA) | ||
| Specificity | CD14 antibody detects endogenous level of CD14 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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