Anti-STAT3 Antibody
Catalog No : IGX-44809
262.00€
188.00€
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| Description | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PMID:10688651, PMID:12359225, PMID:12873986, PMID:15194700, PMID:17344214, PMID:18242580, PMID:23084476, PMID:31462771). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PMID:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PMID:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PMID:12359225). Activated by IL31 through IL31RA (PMID:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PMID:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PMID:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation . May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PMID:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PMID:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion . | ||
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| Other names | Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF | ||
| Cellular localization | Cytoplasm, Nucleus | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P40763 | ||
| Product name | Anti-STAT3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44809 | ||
| Supplier’s Catalog No | IGX-44809 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF, IP | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:500, IP: 1:200-1:2000 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Signal transducer and activator of transcription 3 protein (50-240AA) | ||
| Specificity | STAT3 antibody detects endogenous level of STAT3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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