Anti-OCRL Antibody
Catalog No : IGX-44880
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PMID:7761412, PMID:15474001, PMID:9430698, PMID:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PMID:7761412, PMID:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PMID:21971085). Involved in primary cilia assembly (PMID:22228094, PMID:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PMID:22072788). | ||
|---|---|---|---|
| Other names | Inositol polyphosphate 5-phosphatase OCRL-1, EC 3.1.3.36, Lowe oculocerebrorenal syndrome protein, OCRL, INPP5F OCRL1 | ||
| Cellular localization | Lysosome, Trans-Golgi Network, Early Endosome Membrane, Endosome, Phagosome Membrane, Clathrin-Coated Pit, Photoreceptor Outer Segment, Cilium, Cytoplasmic Vesicle | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q01968 | ||
| Product name | Anti-OCRL Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44880 | ||
| Supplier’s Catalog No | IGX-44880 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Inositol polyphosphate 5-phosphatase OCRL-1 protein (121-271AA) | ||
| Specificity | OCRL antibody detects endogenous level of OCRL protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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