Anti-KDM6A Antibody
Catalog No : IGX-44885
262.00€
188.00€
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| Description | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PMID:17851529, PMID:17713478, PMID:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PMID:17851529, PMID:17713478, PMID:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PMID:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PMID:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression . | ||
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| Other names | Lysine-specific demethylase 6A, EC 1.14.11.-, Histone demethylase UTX, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein, KDM6A, UTX | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O15550 | ||
| Product name | Anti-KDM6A Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44885 | ||
| Supplier’s Catalog No | IGX-44885 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Lysine-specific demethylase 6A protein (620-749AA) | ||
| Specificity | KDM6A antibody detects endogenous level of KDM6A protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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