Anti-SKA1 Antibody
Catalog No : IGX-44919
262.00€
188.00€
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| Description | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PMID:17093495, PMID:19289083, PMID:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PMID:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PMID:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PMID:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PMID:23085020). In the complex, it mediates the interaction with microtubules (PMID:19289083, PMID:23085020). | ||
|---|---|---|---|
| Other names | Spindle and kinetochore-associated protein 1, SKA1, C18orf24 | ||
| Cellular localization | Cytoskeleton, Spindle, Kinetochore | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q96BD8 | ||
| Product name | Anti-SKA1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44919 | ||
| Supplier’s Catalog No | IGX-44919 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Spindle and kinetochore-associated protein 1 protein (61-134AA) | ||
| Specificity | SKA1 antibody detects endogenous level of SKA1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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