Anti-TIMELESS Antibody
Catalog No : IGX-44975
262.00€
188.00€
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| Description | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PMID:9856465, PMID:17141802, PMID:17296725, PMID:23418588, PMID:26344098). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PMID:17141802, PMID:17296725). TIMELESS promotes TIPIN nuclear localization (PMID:17141802, PMID:17296725). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PMID:17141802, PMID:17296725, PMID:26344098, PMID:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PMID:26344098, PMID:30356214). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PMID:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PMID:23418588). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PMID:9856465). May also play an important role in epithelial cell morphogenesis and formation of branching tubules . | ||
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| Other names | Protein timeless homolog, hTIM, TIMELESS, TIM TIM1 TIMELESS1 | ||
| Cellular localization | Chromosome, Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UNS1 | ||
| Product name | Anti-TIMELESS Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44975 | ||
| Supplier’s Catalog No | IGX-44975 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Protein timeless homolog protein (1004-1131AA) | ||
| Specificity | TIMELESS antibody detects endogenous level of TIMELESS protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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