Anti-KAT2A Antibody
Catalog No : IGX-45133
262.00€
188.00€
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| Description | Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PMID:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PMID:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PMID:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PMID:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PMID:17301242, PMID:19103755, PMID:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PMID:17301242, PMID:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PMID:17301242, PMID:19103755, PMID:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PMID:29973595, PMID:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling . Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression . Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) . Regulates embryonic stem cell (ESC) pluripotency and differentiation . Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PMID:17301242, PMID:27796307, PMID:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PMID:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PMID:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PMID:31542297). (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. | ||
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| Other names | Histone acetyltransferase KAT2A, EC 2.3.1.48, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, hGCN5, Histone succinyltransferase KAT2A, EC 2.3.1.-, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5 GCN5L2 | ||
| Cellular localization | Nucleus, Cytoskeleton, Centrosome, Chromosome | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q92830 | ||
| Product name | Anti-KAT2A Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45133 | ||
| Supplier’s Catalog No | IGX-45133 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Histone acetyltransferase KAT2A protein (302-537AA) | ||
| Specificity | KAT2A antibody detects endogenous level of KAT2A protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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