Anti-WDR24 Antibody
Catalog No : IGX-45134
262.00€
188.00€
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| Description | As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PMID:23723238, PMID:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PMID:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PMID:26449471, PMID:26586190, PMID:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PMID:27166823). | ||
|---|---|---|---|
| Other names | GATOR complex protein WDR24, WD repeat-containing protein 24, WDR24, C16orf21 | ||
| Cellular localization | Lysosome Membrane | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q96S15 | ||
| Product name | Anti-WDR24 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45134 | ||
| Supplier’s Catalog No | IGX-45134 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human GATOR complex protein WDR24 protein (1-298AA) | ||
| Specificity | WDR24 antibody detects endogenous level of WDR24 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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