Anti-MACF1 Antibody
Catalog No : IGX-45140
262.00€
188.00€
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| Description | Isoform 2: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PMID:15265687, PMID:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PMID:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane . Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics . Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PMID:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PMID:15265687). Plays a key role in wound healing and epidermal cell migration . Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells . As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development . | ||
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| Other names | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, 620 kDa actin-binding protein, ABP620, Actin cross-linking family protein 7, Macrophin-1, Trabeculin-alpha, MACF1, ABP620 ACF7 KIAA0465 KIAA1251 | ||
| Cellular localization | Golgi Apparatus, Membrane, Ruffle Membrane, Cytoskeleton, Cytoplasm | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UPN3 | ||
| Product name | Anti-MACF1 Antibody | ||
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| Catalog No | IGX-45140 | ||
| Supplier’s Catalog No | IGX-45140 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA) | ||
| Specificity | MACF1 antibody detects endogenous level of MACF1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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