Anti-PSENEN Antibody
Catalog No : IGX-45154
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PMID:12522139, PMID:12763021, PMID:12740439, PMID:12679784, PMID:24941111, PMID:30598546, PMID:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PMID:12522139, PMID:12763021, PMID:12740439, PMID:12679784, PMID:24941111). | ||
|---|---|---|---|
| Other names | Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN, PEN2 | ||
| Cellular localization | Golgi Stack Membrane, Multi-Pass Membrane, Endoplasmic Reticulum Membrane, Membrane, Membrane | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9NZ42 | ||
| Product name | Anti-PSENEN Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45154 | ||
| Supplier’s Catalog No | IGX-45154 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Peptide sequence from Human Gamma-secretase subunit PEN-2 protein (39-57AA) | ||
| Specificity | PSENEN antibody detects endogenous level of PSENEN protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved