Anti-NUDT15 Antibody
Catalog No : IGX-45185
262.00€
188.00€
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| Description | May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PMID:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PMID:22556419, PMID:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PMID:26238318, PMID:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PMID:26238318, PMID:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PMID:19419956). | ||
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| Other names | Nucleotide triphosphate diphosphatase NUDT15, EC 3.6.1.9, MutT homolog 2, MTH2, Nucleoside diphosphate-linked moiety X motif 15, Nudix motif 15, Nucleoside diphosphate-linked to another moiety X hydrolase 15, Nudix hydrolase 15, NUDT15, MTH2 | ||
| Cellular localization | Cytosol | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9NV35 | ||
| Product name | Anti-NUDT15 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45185 | ||
| Supplier’s Catalog No | IGX-45185 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:200-1:500, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Nucleotide triphosphate diphosphatase NUDT15 protein (1-164AA) | ||
| Specificity | NUDT15 antibody detects endogenous level of NUDT15 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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