Anti-KCNC3 / Kv3.3 Antibody
Catalog No : IGX-45242
262.00€
188.00€
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| Description | Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PMID:10712820, PMID:26997484, PMID:22289912, PMID:23734863, PMID:16501573, PMID:19953606, PMID:21479265, PMID:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca2+ channels and cellular Ca2+ homeostasis . Required for normal motor function (PMID:23734863, PMID:16501573, PMID:19953606, PMID:21479265, PMID:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PMID:26997484). | ||
|---|---|---|---|
| Other names | Potassium voltage-gated channel subfamily C member 3, KSHIIID, Voltage-gated potassium channel subunit Kv3.3, KCNC3 | ||
| Cellular localization | Membrane, Multi-Pass Membrane, Presynaptic Membrane, Dendritic Spine Membrane, Cytoskeleton, Perikaryon, Axon, Dendrite, Cell Cortex | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q14003 | ||
| Product name | Anti-KCNC3 / Kv3.3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45242 | ||
| Supplier’s Catalog No | IGX-45242 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:200-1:500, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Potassium voltage-gated channel subfamily C member 3 protein (638-745AA) | ||
| Specificity | KCNC3 antibody detects endogenous level of KCNC3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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