Anti-MMADHC Antibody
Catalog No : IGX-45311
262.00€
188.00€
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| Description | Involved in cobalamin metabolism and trafficking (PMID:18385497, PMID:23415655, PMID:24722857, PMID:26364851). Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) (PMID:18385497,PMID:23415655, PMID:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PMID:26364851). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PMID:27771510). | ||
|---|---|---|---|
| Other names | Methylmalonic aciduria and homocystinuria type D protein, mitochondrial, CblD, MMADHC, C2orf25 CL25022 | ||
| Cellular localization | Cytoplasm, Mitochondrion | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9H3L0 | ||
| Product name | Anti-MMADHC Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45311 | ||
| Supplier’s Catalog No | IGX-45311 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:200-1:500, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Methylmalonic aciduria and homocystinuria type D protein, mitochondrial protein (26-142AA) | ||
| Specificity | MMADHC antibody detects endogenous level of MMADHC protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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