Anti-EMP2 Antibody
Catalog No : IGX-45318
262.00€
188.00€
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| Description | Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PMID:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins . Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity . Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PMID:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PMID:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PMID:21637765, PMID:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PMID:19494199). Positively regulates cell proliferation (PMID:24814193). Plays a role during cell death and cell blebbing (PMID:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PMID:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PMID:16487956). May play a role in glomerular filtration . | ||
|---|---|---|---|
| Other names | Epithelial membrane protein 2, EMP-2, Protein XMP, EMP2, XMP | ||
| Cellular localization | Plasma Membrane, Membrane, Apical Membrane, Golgi Apparatus Membrane, Multi-Pass Membrane, Nucleus, Membrane Raft, Cytoplasm | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P54851 | ||
| Product name | Anti-EMP2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45318 | ||
| Supplier’s Catalog No | IGX-45318 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:200-1:500, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Epithelial membrane protein 2 protein (22-66AA) | ||
| Specificity | EMP2 antibody detects endogenous level of EMP2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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