Anti-OTOP1 Antibody
Catalog No : IGX-45365
262.00€
188.00€
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| Description | Proton-selective channel that specifically transports protons into cells (PMID:29371428). Proton channel activity is only weakly-sensitive to voltage . Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PMID:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration . Probably acts by maintaining the pH appropriate for formation of otoconia . Regulates purinergic control of intracellular calcium in vestibular supporting cells . May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol . Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction . | ||
|---|---|---|---|
| Other names | Otopetrin-1, OTOP1 | ||
| Cellular localization | Membrane, Multi-Pass Membrane | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q7RTM1 | ||
| Product name | Anti-OTOP1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45365 | ||
| Supplier’s Catalog No | IGX-45365 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:200-1:500, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Proton channel OTOP1 protein (414-544AA) | ||
| Specificity | OTOP1 antibody detects endogenous level of OTOP1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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