Anti-TBCD Antibody
Catalog No : IGX-45374
262.00€
188.00€
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| Description | Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PMID:10722852, PMID:10831612, PMID:11847227, PMID:20740604, PMID:27666370, PMID:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PMID:27666370). Involved in neuron morphogenesis (PMID:27666374). | ||
|---|---|---|---|
| Other names | Tubulin-specific chaperone D, Beta-tubulin cofactor D, tfcD, SSD-1, Tubulin-folding cofactor D, TBCD, KIAA0988 SSD1 TFCD | ||
| Cellular localization | Plasma Membrane, Lateral Membrane, Cytoskeleton, Centrosome, Tight Junction, Cytoplasm, Adherens Junction | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9BTW9 | ||
| Product name | Anti-TBCD Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45374 | ||
| Supplier’s Catalog No | IGX-45374 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:200-1:500, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Tubulin-specific chaperone D protein (2-96AA) | ||
| Specificity | TBCD antibody detects endogenous level of TBCD protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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