Anti-LRP1 Antibody
Catalog No : IGX-45423
262.00€
188.00€
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| Description | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PMID:11907044, PMID:12888553, PMID:12713657). Acts as an alpha-2-macroglobulin receptor (PMID:26142438). (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. | ||
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| Other names | Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD antigen CD91, [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD,], LRP1, A2MR APR | ||
| Cellular localization | Plasma Membrane, Membrane, Single-Pass Type I Membrane, Coated Pit, Peripheral Membrane, Extracellular Side, Nucleus, Cytoplasm, Cytoskeleton, Microtubule Organizing Center, Postsynaptic Golgi Apparatus | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q07954 | ||
| Product name | Anti-LRP1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45423 | ||
| Supplier’s Catalog No | IGX-45423 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:200-1:500, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Peptide sequence from Human Prolow-density lipoprotein receptor-related protein 1 protein (3924-3942AA) | ||
| Specificity | LRP1 antibody detects endogenous level of LRP1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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