Anti-ALOX12B Antibody
Catalog No : IGX-45532
262.00€
188.00€
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| Description | Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PMID:9837935, PMID:9618483, PMID:21558561). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PMID:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PMID:21558561). May also play a role in the regulation of the expression of airway mucins (PMID:22441738). | ||
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| Other names | Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, EC 1.13.11.-, Epidermis-type lipoxygenase 12, ALOX12B | ||
| Cellular localization | Cytoplasm, Perinuclear Region | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O75342 | ||
| Product name | Anti-ALOX12B Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45532 | ||
| Supplier’s Catalog No | IGX-45532 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:500-1:1000 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA) | ||
| Specificity | ALOX12B antibody detects endogenous level of ALOX12B protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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