Anti-NUDT5 Antibody
Catalog No : IGX-45573
262.00€
188.00€
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| Description | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PMID:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PMID:10567213, PMID:10722730, PMID:19699693, PMID:21389046, PMID:17052728). Can also hydrolyze other nucleotide sugars with low activity (PMID:19699693, PMID:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PMID:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PMID:27257257). Does not play a role in U8 snoRNA decapping activity . Binds U8 snoRNA . | ||
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| Other names | ADP-sugar pyrophosphatase, EC 3.6.1.13, 8-oxo-dGDP phosphatase, EC 3.6.1.58, Nuclear ATP-synthesis protein NUDIX5, EC 2.7.7.96, Nucleoside diphosphate-linked moiety X motif 5, Nudix motif 5, hNUDT5, YSA1H, NUDT5, NUDIX5 | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UKK9 | ||
| Product name | Anti-NUDT5 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45573 | ||
| Supplier’s Catalog No | IGX-45573 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:500-1:1000, IF: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human ADP-sugar pyrophosphatase protein (34-166AA) | ||
| Specificity | NUDT5 antibody detects endogenous level of NUDT5 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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