Anti-PKD1 Antibody
Catalog No : IGX-45589
262.00€
188.00€
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| Description | Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PMID:27214281). Both PKD1 and PKD2 are required for channel activity (PMID:27214281). Involved in renal tubulogenesis (PMID:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium . Acts as a regulator of cilium length, together with PKD2 . The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling . The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling . May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. | ||
|---|---|---|---|
| Other names | Polycystin-1, PC1, Autosomal dominant polycystic kidney disease 1 protein, PKD1 | ||
| Cellular localization | Golgi Apparatus, Endoplasmic Reticulum, Plasma Membrane, Membrane, Multi-Pass Membrane, Cilium | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P98161 | ||
| Product name | Anti-PKD1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45589 | ||
| Supplier’s Catalog No | IGX-45589 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:500-1:1000, IF: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Polycystin-1 protein (615-753AA) | ||
| Specificity | PKD1 antibody detects endogenous level of PKD1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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