Anti-NPHP4 Antibody
Catalog No : IGX-45614
262.00€
188.00€
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| Description | Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PMID:19755384, PMID:21565611). Does not seem to be strictly required for ciliogenesis (PMID:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 . In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PMID:21498478, PMID:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PMID:21555462). | ||
|---|---|---|---|
| Other names | Nephrocystin-4, Nephroretinin, NPHP4, KIAA0673 | ||
| Cellular localization | Nucleus, Cytoskeleton, Cilium Basal Body, Centrosome, Tight Junction | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O75161 | ||
| Product name | Anti-NPHP4 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45614 | ||
| Supplier’s Catalog No | IGX-45614 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:500-1:1000, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Nephrocystin-4 protein (397-543AA) | ||
| Specificity | NPHP4 antibody detects endogenous level of NPHP4 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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