Anti-EYA1 Antibody
Catalog No : IGX-45624
262.00€
188.00€
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| Description | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PMID:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis . Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) . Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears . Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 . | ||
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| Other names | Eyes absent homolog 1, EC 3.1.3.16, EC 3.1.3.48, EYA1 | ||
| Cellular localization | Cytoplasm, Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q99502 | ||
| Product name | Anti-EYA1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45624 | ||
| Supplier’s Catalog No | IGX-45624 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:500-1:1000, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Eyes absent homolog 1 protein (168-321AA) | ||
| Specificity | EYA1 antibody detects endogenous level of EYA1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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